Bill Murray As Hunter S. Thompson

The film music was scored by Neil Young, who sings the opening theme, "Home on the Range" accompanied by a harmonica. Variations on "Home on the Range" are played by Young on electric guitar as "Ode to Wild Bill" and by an orchestra with arrangements by David Blumberg on "Buffalo Stomp". Music in the film included rock and R&B songs by Jimi Hendrix, Bob Dylan, The Temptations, the Four Tops and Creedence Clearwater Revival. Additionally, characters played by Bill Murray and Rene Auberjonois sing lyrics from "Lucy in the Sky with Diamonds".

Where the Buffalo Roam is a 1980 comedy film based on a number of semi-biographical stories written by author Hunter S. Thompson. The film loosely depicts Thompson's rise to fame in the 1970s and his relationship with Chicano attorney and activist Oscar Zeta Acosta